Alpha-ketoglutarate is a chemical already found in your body, but recently it's also been used to make medications, among other helpful supplements. Some of these include treatments for kidney disease, digestion, intestinal disorders, and much more. AKG is a nitrogen scrounger and a source of glutamate and glutamine, which prompts protein synthesis, and provokes protein degradation in your muscles.
Nitrogen is a natural element that is crucial for plants and animals. It allows them to grow, so it's important in our bodies. It creates amino acids, which then create proteins. Also, it's used for nucleic acids as well, which make up our DNA and RNA, as well as our muscles, skin, blood, and hair. Humans and many other animals on our planet require a specific amount of nitrogen to survive.
It's naturally concocted through your body's cells as they produce energy. It aids in the destruction of toxins and harmful waste, prompting your body to flush them out, and it helps avoid new toxins from forming. This includes ammonia, which is caused when your body breaks down protein. Elevated ammonia levels are most common in people who suffer from liver or kidney diseases. If the ammonia levels are too high, they can cause detrimental and irreversible side effects, such as brain damage or coma. For this reason, it's common for doctors to use AKG in those ongoing treatments for people with these unfortunate diseases.
AKG has been known to work well continuously, giving them a good reason to pursue further advantages that it may have for us. For example, AKG is used to prevent blood flow issues during heart surgery and to discourage the breakdown of muscles after a trauma or surgery. Its anti-inflammatory properties are a significant benefit in this process, while it also helps to replenish the muscle.
Health Benefits of Alpha-Ketoglutarate
AKG has a way of working its way through your body, using many avenues. While coursing through you, it helps to repair and build your muscles while also helping to heal any existing injuries. For this reason, it's commonly used during or after procedures. Its effectiveness has been noted during treatment for long-term kidney disease, aiding in the effectiveness of haemodialysis in those undergoing these treatments. Additionally, introducing AKG through an IV can help restore tissue damage where there was once limited blood flow.
A few other things haven’t been proven to be totally accurate, but studies on AKG are still ongoing. Athletic performance has been noticeably improving after a solid five weeks of use. Keep in mind, this goes along with a healthy lifestyle and an appropriate diet. It's also been known to help with pain-inducing conditions, such as arthritis, osteoporosis, and tendon pain. AKG has been shown to reduce pain and increase function in these areas, alongside other useful treatments, of course. Skin appearance, bone health, lung health, infections, and other conditions have also been reported to have been greatly impacted by its use. However, scientists are still researching its effectiveness and ratings for these uses.
Recent evidence also shows the association between myocardial oxidative injury and mitochondrial dysfunction in the pathophysiology of heart failure. Since AKG is a median metabolite of the tricarboxylic acid cycle, it participates in different cellular metabolic pathways. The consistent volume of AKG was found to lower as age increased and was heightened after minor workouts.
Experimental models have also recently shown that dietary AKG minimizes reactive oxygen species (ROS) production and systemic inflammatory cytokine levels, encourages a regular metabolism, prolongs lifespan, and offsets age-related decline.
The effects of AKG on left ventricular (LV) systolic function, the myocardial ROS content, and mitophagy in mice with transverse aortic constriction (TAC) have also been studied recently. AKG supplementation withdrew pressure overload-induced myocardial hypertrophy and fibrosis and enhanced systolic cardiac dysfunction.
These advantages of AKG in the TAC studies may have been achieved by well-developed mitophagy, which discharged flawed mitochondria. Overall AKG increases myocardial (heart muscle) rebuilding, fibrosis, and LV systolic dysfunction in the pressure-overloaded heart by encouraging mitophagy to dispose of faulty mitochondria and lower ROS production AKG most likely has beneficial effects when treating HF.
Side Effects of Alpha-Ketoglutarate
The research also shows that AKG is 'mostly' safe when administered either orally or by IV. This means the research has been somewhat inconclusive, but overall, there have been very few adverse reactions and more benefits. So basically, the good outweighs the bad. Nevertheless, if you are pregnant or breastfeeding, you should avoid all experimental medications, including AKG, due to the lack of conclusive study and potential hazards to your pregnancy or new-born.
Because AKG is already found in our bodies, taking too much of it can cause an adverse reaction you didn't anticipate. Too much of anything isn't good for our bodies, even if our bodies produce it themselves. It's critical to check with your doctor to ensure you're getting the proper dose for your body. This may include undergoing an exam and even blood work to determine what dosage is right for you.
Other Benefits of Alpha-Ketoglutarate
Because of its involvement in cell metabolism and physiology, this drug is also known to be an excellent dietary supplement. AKG is necessary for the corrosion of fatty acids, amino acids, and glucose. Therefore, it offers an abundant supply of energy. While linking carbohydrate and nitrogen metabolism, it maintains amino acids and ammonia detoxification. Furthermore, AKG is known for its cell signalling pathways, which makes it a great addition to enhanced cellular energy status, health, and immunity.
Alongside the metabolism benefits of AKG, there have also been reports that athletes see great results from incorporating this into their fitness routine. Again, not much research has concluded this, but professional athletes and bodybuilders can usually gauge when something is working for them. After all, their goal is to be stronger.
When using AKG as a workout tool, your body is able to focus on building strength while also gaining muscle. Due to its ability to enable protein synthesis while also preventing protein destruction, many professional athletes have decided to use it more frequently. Not to mention, it also aids in the production of nitric oxide. Nitric oxide is crucial when trying to gain muscle. It expands your blood vessels, allowing your blood to flow more freely, and it also wakes up your hormones.
In conjunction with supporting a healthy metabolism and aiding with athletics, AKG also offers anti-aging properties. Metabolism and aging have been known to go hand in hand. The older we get, the less AKG our body produces naturally, which leaves our metabolism sluggish, and also leaves us more vulnerable to sickness and injuries. Our reproduction of AKG varies based on our individual diet, how often we exercise, and how old we are. We recover slower as we age, but by boosting our AKG as we age, we can reverse and prevent disease and injuries from worsening. That's because AKG advances the health of mitochondria, which is the heart of the cell.
The Cellular Connection
Mitochondria produce the energy our cells thrive on, so in order to properly function, this is crucial. Each cell includes thousands of mitochondria, but as we age, they become less effective. This is due to several things, including DNA mutations as cells split, free radicals, or epigenetic alterations. When cells are damaged but don't have the energy to repair themselves, they send signals that interfere with their own natural functions, which in turn leads to aging. AKG is one of the newest but most beneficial forms of anti-aging supplements and can help your cells maintain their health.
You might also be asking yourself, what are epigenetic alterations? Well, this determines which genes are dominant and which are not. The more we age, the more the epigenome is deregulated, which means the genes that work in your Favor may be turned off now, while others that don't benefit you may turn on. When this happens, your cells get confused, which causes them to malfunction, which again advances aging. The good news is you are able to reset the epigenome, and AKG can help! It will prolong the lifespan of your cells, and it's been known to reverse some subtle age-related characteristics.
So far, the testing has mostly been on mice, but humans seem to have recently included themselves in these benefits as well. When we noticed how the lifespan and overall health of these small animals increased owing to the fact that they were given AKG, it was inspiring to scientists to continue further research and see exactly how beneficial AKG can be to humans and animals.